Methods of Dendritic Drugs for Controlled Release in Drug Delivery

Minghui Chai

This technology enables a novel drug delivery method that utilizes dendrimers as a quantitative and controlled mechanism of delivery; biocompatible linkers with biodegradable bonding allow drug molecules to be incorporated into a dendritic structure to form a dendritic drug that consists of a known amount of drug molecules. Each layer of the cascade structure of the dendrimer is designed to contain a known amount of drug, with the largest amount at the periphery and the lowest amount at the core. The dendrimer delivery platform appears to be very flexible with application for many classes of drugs including anti-fungals, anti-inflammatory agents, anticancer drugs and anti-bacterials. The platform could be designed for diverse administration paths: oral, rectal, or parenteral, intravenous, intramuscular, intraperitoneal, intraspinal, intracranial, topical, ocular, and subcutaneous routes.

Center for Biomedical Research

TBD

This center supports state-of-the-art research facilities for biomedical research, promotes and publicizes biomedical research, and aggressively encourages and supports initiatives for support of biomedical research. The center sponsors research presentations and colloquia, provides funds to support pilot research projects, and identifies novel funding. In addition, the center assists with the development and submission of proposals for external funding of major multi-investigator equipment, (b) provides and maintains readily accessible multi-user equipment facilities, and (c) facilitates access to specialized facilities and services. In addition to supporting and promoting collaborations among its members, the center facilitates interactions between members and other institutions, including pharmaceutical and biotechnology companies, and promotes access to biomedical research equipment within the center.

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