PiezoBiosensor for Detecting Complex Environmental and Chemical Agents

Xiangquan Zeng

This technology is an apparatus with multiple piezoelectric mass sensors for use in immunochemical detection of diagnostically relevant analytes. The detection is in real time, and each piezoelectric mass sensor comprises a piezoelectric crystal with a receptor surface containing recombinant antibodies that are specific for a particular antigen. The technology measures the binding of antigens to the recombinant antibodies by tracking a change in mass on the receptor surface which is detected as a change in resonant frequency. This technology emerged from a research program oriented toward developing piezobiosensors and electrochemical sensors for detection in complex environmental and clinical samples. The research program is focused on combining the excellent sensitivity of electrochemical and mass sensing with the superb selectivity of biological recognition processes (e.g., protein-protein interactions, DNA-protein interactions, carbohydrate-protein interactions).

Center for Biomedical Research

TBD

This center supports state-of-the-art research facilities for biomedical research, promotes and publicizes biomedical research, and aggressively encourages and supports initiatives for support of biomedical research. The center sponsors research presentations and colloquia, provides funds to support pilot research projects, and identifies novel funding. In addition, the center assists with the development and submission of proposals for external funding of major multi-investigator equipment, (b) provides and maintains readily accessible multi-user equipment facilities, and (c) facilitates access to specialized facilities and services. In addition to supporting and promoting collaborations among its members, the center facilitates interactions between members and other institutions, including pharmaceutical and biotechnology companies, and promotes access to biomedical research equipment within the center.

Biomaterials synthesis with medical applications

Anja Mueller

Hydrophilic polymers, specifically polysaccharides, are being examined because of their non-adhesive properties. These polymers are synthesized via enzymatic polymerization without toxic solvents or chemicals. Polysaccharide-based materials are used for the development of an improved, artificial, biodegradable skin scaffold for burn victims. Also in development is an anti-thrombogenic coating for artificial heart valves. The coating is being enzymatically synthesized under non-toxic conditions with various copolymers and polymer structures being tested.

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